Born in New York in 1917, Cass Harrison developed his keyboard technique since he was a tender four years of age. He studied classical piano and composition at the prestigious Julliard School. Harrison got his professional wings in the Teddy Powell band, which included in its personnel such noted musicians as Ray Wetzel, Charlie Ventura, and Irving Fazola.

Harrison played in Pennsylvania in 1944, subsequently toured with big bands and appeared widely as a soloist, usually leading his own combo. In 1948, he played intermissions at Cafe James in New York. In 1954, he played with a singer at the Hotel Warwick in Philadelphia. Notable in his background was a big jazz band of his own with which he toured South America prior to recording with his trio.

Cass Harrison will be remembered by record fans for his M-G-M albums “The Duke and I” (MGM E3388), and “Wrappin’ It Up” (MGM E3495) both superlative collections of urihackneyed standards by six outstanding pianist-composers: Duke Ellington, Fats Waller, Earl Hines, George Wallington, Horace and Fletcher Henderson.

The first trio album, "The Duke and I," consisting of versions of little-known Duke Ellington compositions, was released in 1956. The reviewer for Billboard wrote: "Harrison is an extremely gifted pianist who ought to be better known. He is technically facile, imaginative, fresh in his harmonic conception and possessed of one of the most rock ribbed beats imaginable." Followed in 1957 by "Wrappin' It Up." Critic John S. Wilson described the performances as "a lightly swinging, unencumbered workout."

Around 1960, Harrison led a trio performing at the Park Central Hotel in New York. Harrison later moved to Puerto Rico.

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